Comparison of retinochoroidal vascular and structural changes after half-dose photodynamic therapy versus half-fluence photodynamic therapy based on optical coherence tomography angiography in eyes with chronic central serous chorioretinopathy

Purpose: To compare the efficacy of half-fluence photodynamic therapy (PDT) and half-dose PDT on the choroidal structure via perfusion of the retinal plexus and choriocapillaris in eyes with chronic central serous chorioretinopathy (cCSCR). Materials and Methods: This retrospective study included 43 eyes in 43 patients with cCSCR. Patients in group 1 received half-fluence (verteporfin 6 mg m –2) PDT and those in group 2 received half-dose (verteporfin 3 mg m–2) PDT. Enhanced depth imaging optical coherence tomography (EDI-OCT) and optical coherence tomography angiography (OCTA) images were recorded 1 day before and 3 months after PDT. Total choroidal area (TCA), luminal area (LA), a nd stromal area (SA) were calculated using Image J software. Results: From baseline to 3 months post PDT TCA decreased from 2.43 ± 0.47 mm2 to 2.08 ± 0.59 mm2 (P
Source: Ophthalmologica - Category: Opthalmology Source Type: research