3,4,5-Trimethoxycinnamate thymol ester inhibits melanogenesis in normal human melanocytes and 3D human epidermal equivalents via the PGC-1 α-independent PPARγ partial agonism

3,4,5-Trimethoxycinnamate thymol ester (TCTE), an anti-melanogenic cosmetic agent prescribed currently, promotes adiponectin synthesis during adipogenesis in human bone marrow mesenchymal stem cells (hBM-MSCs). Adiponectin inhibits melanin biosynthesis and its biosynthesis is directly regulated by peroxisome proliferator-activated receptor (PPAR) γ. In this regard, TCTE may potentially affect PPARγ activity. However, contradicting effects of PPARγ agonists with different chemical structures on human melanogenesis have been reported.

Source: Journal of Dermatological Science - February 28, 2022 Category: Dermatology Authors: Hyejin Ko, Hyunjung Choi, Yujia Han, Seungchan An, Daejin Min, Won-Seok Park, Sun Hee Jin, Hyoung-June Kim, Minsoo Noh Source Type: research