Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes [Biochemistry]

The mitotic (or spindle assembly) checkpoint system ensures accurate chromosome segregation in mitosis by preventing the onset of anaphase until correct bipolar attachment of sister chromosomes to the mitotic spindle is attained. It acts by promoting the assembly of a mitotic checkpoint complex (MCC), composed of mitotic checkpoint proteins BubR1,...

Source: Proceedings of the National Academy of Sciences - February 25, 2022 Category: Science Authors: Sharon Kaisari, Shirly Miniowitz-Shemtov, Danielle Sitry-Shevah, Pnina Shomer, Guennadi Kozlov, Kalle Gehring, Avram Hershko Tags: Biochemistry Biological Sciences Source Type: research