Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization [Medical Sciences]

Therapeutic strategies directed at the tumor surfaceome (TS), including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here,...

Source: Proceedings of the National Academy of Sciences - February 25, 2022 Category: Science Authors: Valeria Governa, Hugo Talbot, Kelin Goncalves de Oliveira, Myriam Cerezo–Magana, Anna Bang–Rudenstam, Maria C. Johansson, Ann–Sofie Mansson, Karin Forsberg–Nilsson, Gyorgy Marko–Varga, Julio Enriquez Perez, Anna Darabi, Johan Tags: Medical Sciences Biological Sciences Source Type: research