CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel

Myocardial infarction (MI) produces acute changes in strain and stiffness within the infarct that can affect remote areas of the left ventricle (LV) and drive pathological remodeling. We hypothesized that intramyocardial delivery of a hydrogel within the MI region would lower wall stress and reduce adverse remodeling in Yorkshire pigs (n  = 5). 99mTc-Tetrofosmin SPECT imaging defined the location and geometry of induced MI and border regions in pigs, and in vivo and ex vivo contrast cine computed tomography (cineCT) quantified deformations of the LV myocardium.

Source: Journal of Molecular and Cellular Cardiology - February 25, 2022 Category: Cytology Authors: D.E. Midgett, S.L. Thorn, S.S. Ahn, S. Uman, R. Avendano, I. Melvinsdottir, T. Lysyy, S. Kim, J.S. Duncan, J.D. Humphrey, X. Papademetris, J.A. Burdick, A.J. Sinusas Source Type: research