Cell-Free DNA Derived From Neutrophils Triggers Type 1 Interferon Signature in Neuromyelitis Optica Spectrum Disorder

Discussion
Our study highlights the previously unrevealed role of cfDNA predominantly released by neutrophil in the induction of IFN-1 signature in NMOSD and further indicate a novel pharmacologic target in NMOSD.

Source: Neurology Neuroimmunology and Neuroinflammation - February 24, 2022 Category: Neurology Authors: Murata, H., Kinoshita, M., Yasumizu, Y., Motooka, D., Beppu, S., Shiraishi, N., Sugiyama, Y., Kihara, K., Tada, S., Koda, T., Konaka, H., Takamatsu, H., Kumanogoh, A., Okuno, T., Mochizuki, H. Tags: Autoimmune diseases, Devic's syndrome, Optic neuritis; see Neuro-ophthalmology/Optic Nerve Article Source Type: research