Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients [Immunology and Inflammation]

Cytomegalovirus (CMV) infection is associated with graft rejection in renal transplantation. Memory-like natural killer (NK) cells expressing NKG2C and lacking FcεRIγ are established during CMV infection. Additionally, CD8+ T cells expressing NKG2C have been observed in some CMV-seropositive patients. However, in vivo kinetics detailing the development and differentiation of these...

Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Kenichi Ishiyama, Janice Arakawa-Hoyt, Oscar A. Aguilar, Izabella Damm, Parhom Towfighi, Tara Sigdel, Stanley Tamaki, Joel Babdor, Matthew H. Spitzer, Elaine F. Reed, Minnie M. Sarwal, Lewis L. Lanier, CMV Systems Immunobiology Group Tags: Immunology and Inflammation Biological Sciences Source Type: research