Population Pharmacokinetic Model for Tramadol and O-desmethyltramadol in Older Patients

ConclusionExposure to tramadol increased with increased frailty and reduced CrCL. Prescribers should consider patients frailty status and CrCL to minimise the risk of tramadol toxicity in such cohort of patients.

http://rd.springer.com/10.1007/s13318-022-00756-x

Source: European Journal of Drug Metabolism and Pharmacokinetics - February 15, 2022 Category: Drugs & Pharmacology Source Type: research