Viral PB1-F2 and host IFN-{gamma} guide ILC2 and T cell activity during influenza virus infection [Immunology and Inflammation]

Functional plasticity of innate lymphoid cells (ILCs) and T cells is regulated by host environmental cues, but the influence of pathogen-derived virulence factors has not been described. We now report the interplay between host interferon (IFN)-γ and viral PB1-F2 virulence protein in regulating the functions of ILC2s and T cells...

Source: Proceedings of the National Academy of Sciences - February 15, 2022 Category: Science Authors: Tarani Kanta Barman, Victor C. Huber, Jesse L. Bonin, Danielle Califano, Sharon L. Salmon, Andrew N. J. McKenzie, Dennis W. Metzger Tags: Immunology and Inflammation Biological Sciences Source Type: research