Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver [Physiology]

The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic metabolism. Many genes induced in response to pharmacologic LXR agonism have been defined; however, the transcriptional consequences of loss of LXR binding to its genomic targets are less well characterized. Here, we addressed how deletion...

Source: Proceedings of the National Academy of Sciences - February 10, 2022 Category: Science Authors: Lara Bideyan, Wenxin Fan, Karolina Elzbieta Kaczor–Urbanowicz, Christina Priest, David Casero, Peter Tontonoz Tags: Physiology Biological Sciences Source Type: research