Somatostatin-type and allatostatin-C-type neuropeptides are paralogous and have opposing myoregulatory roles in an echinoderm [Physiology]

Somatostatin (SS) and allatostatin-C (ASTC) are inhibitory neuropeptides in chordates and protostomes, respectively, which hitherto were identified as orthologs. However, echinoderms have two SS/ASTC-type neuropeptides (SS1 and SS2), and here, our analysis of sequence data indicates that SS1 is an ortholog of ASTC and SS2 is an ortholog of SS....

Source: Proceedings of the National Academy of Sciences - February 10, 2022 Category: Science Authors: Ya Zhang, Luis Alfonso Yanez–Guerra, Ana B. Tinoco, Nayeli Escudero Castelan, Michaela Egertova, Maurice R. Elphick Tags: Physiology Biological Sciences Source Type: research