Protein kinase C{gamma} in cerebellar Purkinȷe cells regulates Ca2+-activated large-conductance K+ channels and motor coordination [Neuroscience]

The cerebellum, the site where protein kinase C (PKC) was first discovered, contains the highest amount of PKC in the central nervous system, with PKCγ being the major isoform. Systemic PKCγ-knockout (KO) mice showed impaired motor coordination and deficient pruning of surplus climbing fibers (CFs) from developing cerebellar Purkinje cells...

Source: Proceedings of the National Academy of Sciences - February 10, 2022 Category: Science Authors: Masashi Watanave, Nobutaka Takahashi, Nobutake Hosoi, Ayumu Konno, Hikaru Yamamoto, Hiroyuki Yasui, Mika Kawachi, Takuro Horii, Yasunori Matsuzaki, Izuho Hatada, Hirokazu Hirai Tags: Neuroscience Biological Sciences Source Type: research