A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics [Biophysics and Computational Biology]

Mitochondrial inner NEET (MiNT) and the outer mitochondrial membrane (OMM) mitoNEET (mNT) proteins belong to the NEET protein family. This family plays a key role in mitochondrial labile iron and reactive oxygen species (ROS) homeostasis. NEET proteins contain labile [2Fe-2S] clusters which can be transferred to apo-acceptor proteins. In eukaryotes,...

Source: Proceedings of the National Academy of Sciences - February 8, 2022 Category: Science Authors: Ola Karmi, Henri–Baptiste Marȷault, Fang Bai, Susmita Roy, Yang–Sung Sohn, Merav Darash Yahana, Faruck Morcos, Konstantinos Ioannidis, Yaakov Nahmias, Patricia A. Jennings, Ron Mittler, Jose N. Onuchic, Rachel Nechushtai Tags: Physical Sciences Source Type: research