Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release [Biochemistry]

How can exactly six SNARE complexes be assembled under each synaptic vesicle? Here we report cryo-EM crystal structures of the core domain of Munc13, the key chaperone that initiates SNAREpin assembly. The functional core of Munc13, consisting of C1–C2B–MUN–C2C (Munc13C) spontaneously crystallizes between phosphatidylserine-rich bilayers in two distinct conformations, each...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biochemistry Biological Sciences Source Type: research