MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function [Genetics]

Multidrug Resistance Proteins (MRPs) are transporters that play critical roles in cancer even though the physiological substrates of these enigmatic transporters are poorly elucidated. In Caenorhabditis elegans, MRP5/ABCC5 is an essential heme exporter because mrp-5 mutants are unviable due to their inability to export heme from the intestine to extraintestinal...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Genetics Biological Sciences Source Type: research