SR-B1 ’s Next Top Model: Structural Perspectives on the Functions of the HDL Receptor

AbstractPurpose of ReviewThe binding of high-density lipoprotein (HDL) to its primary receptor, scavenger receptor class B type 1 (SR-B1), is critical for lowering plasma cholesterol levels and reducing cardiovascular disease risk. This review provides novel insights into how the structural elements of SR-B1 drive efficient function with an emphasis on bidirectional cholesterol transport.Recent FindingsWe have generated a new homology model of full-length human SR-B1 based on the recent resolution of the partial structures of other class B scavenger receptors. Interrogating this model against previously published observations allows us to generate structurally informed hypotheses about SR-B1 ’s ability to mediate HDL-cholesterol (HDL-C) transport. Furthermore, we provide a structural perspective as to why human variants of SR-B1 may result in impaired HDL-C clearance.SummaryA comprehensive understanding of SR-B1 ’s structure–function relationships is critical to the development of therapeutic agents targeting SR-B1 and modulating cardiovascular disease risk.
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research