DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor [Applied Physical Sciences]

Nature evolves molecular interaction networks through persistent perturbation and selection, in stark contrast to drug discovery, which evaluates candidates one at a time by screening. Here, nature’s highly parallel ligand-target search paradigm is recapitulated in a screen of a DNA-encoded library (DEL; 73,728 ligands) against a library of RNA structures...

Source: Proceedings of the National Academy of Sciences - February 2, 2022 Category: Science Authors: Raphael I. Benhamou, Blessy M. Suresh, Yuquan Tong, Wesley G. Cochrane, Valerie Cavett, Simon Vezina-Dawod, Daniel Abegg, Jessica L. Childs-Disney, Alexander Adibekian, Brian M. Paegel, Matthew D. Disney Tags: Applied Physical Sciences, Biochemistry Biological Sciences Source Type: research