Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets

ConclusionsThe PLT proteome analyzed in this study suggests that PLTs actively respond toP. vivax infection. Altogether, our findings suggest important roles of PF4/CXCL4 during uncomplicatedP. vivax infection through a possible intracellular localization. Our study shows that platelets are active responders toP. vivax infection, inhibiting intraerythrocytic parasite development. Future studies are needed to further investigate the molecular pathways of interaction between platelet proteins found in this study and host response, which could affect parasite control as well as disease progression.
Source: Clinical Proteomics - Category: Biochemistry Source Type: research