HLA-DPB1 E69 genotype and exposure in beryllium sensitisation and disease

Conclusions
Risk of CBD increases with E69 allele frequency and increasing exposure, although no gene by environment interaction was found. A decreased risk of BeS with increasing exposure and lack of exposure response in CBD cases may be due to the limitations of reconstructed exposure estimates. Although reducing exposure may not prevent BeS, it may reduce CBD and the associated health effects, especially in those carrying E69 alleles.

Source: Occupational and Environmental Medicine - January 13, 2022 Category: Occupational Health Authors: Crooks, J., Mroz, M. M., VanDyke, M., McGrath, A., Schuler, C., McCanlies, E. C., Virji, M. A., Rosenman, K. D., Rossman, M., Rice, C., Monos, D., Fingerlin, T. E., Maier, L. A. Tags: Workplace Source Type: research