Anti-diabetic and hepato-renal protective potential of hydroalcoholic extract of Teucrium polium in alloxan-induced diabetic rats

This study ’s objective was to determine the effects of hydroalcoholic extract ofTeucrium polium (T. polium) on histopathological and biochemical markers of the liver and kidney in diabetic rats. In this experimental study, 60 male Wistar rats were divided to healthy control (group 1), diabetic control (group 2, these two groups received distilled water), treated diabetic positive control (group 3) using a dose 150  mg/kg/day metformin, and two groups treated with doses 400 (group 4) and 800 (group 5) mg/kg/BW ofT. polium extracts via gavage feeding for 8  weeks. Diabetes mellitus was experimentally induced by one dose intraperitoneally injection of alloxan 120 mg/kg. Comparison of normal rats and diabetic rats revealed that kidney tissue would experience tubular changes in diabetic rats. Histopathological examination revealed a reduction in the tu bular changes of kidney tissue following treatment with the extract. In addition, theT. polium extract was able to reduce the infiltration of PMN cells in the liver tissue. Also,T. polium significantly decreased blood glucose, malondialdehyde, and creatinine levels. Results suggested thatT. polium extract can decrease hepato-renal damages by influencing histopathological and biochemical markers in diabetic rats.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research