Chronic effects of blast injury on the microvasculature in a transgenic mouse model of Alzheimer ’s disease related Aβ amyloidosis

ConclusionIn conditions of high brain concentrations of human A β, bTBI exposure results in reduced AQP4 expression at the astroglia-microvascular interface, and in chronic capillary proliferation like what has been reported in AD. Long term microvascular changes after bTBI may contribute to the risk for developing chronic neurodegenerative disease later in lif e.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research