Metallo-?-lactamase, extended spectrum ?-lactamase and mcr-1 gene as major therapeutic challenges

Antibiotic resistance is a major problem worldwide. There are different types of resistance specially in Gram-negative bacteria. Emergence of carbapenem resistance in Enterobacteriaceae, Pseudomonas, Acinetobacter and Klebsiella spp. is a main public health problem in the world. The ?-lactamases are classified according to their functional similarities or molecular structures. There are two various families of ?-lactamases that are found in bacteria. One of the causes of bacterial resistance is failure in treatment. Metallo-?-lactamases (MBLs) are associated with serine protease that are categorized in Ambler class B. MBL gene transfer is horizontally by mobile genetic elements. Extended spectrum ?-lactamases are the main class of ?-lactamases and show resistance to cephalosporins. In this review, we focus on special resistance genes and their origin. Also, we try to demonstrate new treatments for resistant bacteria.
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: MICROBIOLOGY Source Type: research