Repercussion of cAMP and EPAC in Memory and Signaling
Drug Res (Stuttg) DOI: 10.1055/a-1657-2464It is well recognized that cyclic adenosine monophosphate (cAMP) signaling within
neurons plays a key role in the foundation of long-term memories. Memory storage
is the process that demands the movement of signals, neural plasticity, and the
molecules which can transfer the signals from the sensory neuron to the dorsal
root ganglion (DRG) neurons and later into the temporal region of the brain. The
discovery of cAMP in 1958 as the second messenger also had a role in memory
formation and other neural aspects. Further, in 1998 the scientists found that
cAMP does not just activate protein kinase A (PKA) but also exchange protein
directly activated by cAMP (Epac) which has an active role to play in
hyperalgesia, memory, and signaling. The cAMP has three targets,
hyperpolarization-activated cyclic nucleotide modulated (HCN) channels, protein
kinase A (PKA), and exchange protein activated by cAMP (Epac). Different
research has exposed that both PKA and HCN channels are significant for
long-term memory creation. Epac is a cAMP-dependent guanine nucleotide exchange
factor for the small G proteins including Rap1. However, slight information is
there about the role of Epac in this process. The effects of cAMP are
predominantly imparted by activating protein kinase A (PKA) and the more n...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Naz, Sabreena Mahmood, Tarique Ahsan, Farogh Rizvi, Ali Abbas Shamim, Arshiya Tags: Review Source Type: research