Neuroinflammation, diabetes, and COVID-19: Perspectives coming from Ca2+/cAMP signalling

Curr Drug Res Rev. 2021 Dec 31. doi: 10.2174/2589977514666211231141401. Online ahead of print.ABSTRACTBACKGROUND: A link between inflammatory diseases, e.g., epilepsy, dementia, diabetes, and COVID-19, has been established. For instance, observational studies with several individuals established that people with epilepsy have shown an enhanced incidence of manifesting dysfunctions related to cognition, e.g., dementia, while people with dementia have a higher incidence of manifesting epilepsy, thus an evident bidirectional relationship between epilepsy and dementia might occur. In addition, epilepsy commonly cooccurs in patients with diabetes, so an association between these two disorders is also discussed. Intriguingly, some reports have also observed a poor prognosis for people with both diabetes and COVID-19. It is recognized that a dyshomeostasis of both Ca2+ and cAMP signalling pathways could be a molecular connection for these disorders.OBJECTIVES: Therefore, clarifying this clinical relationship among epilepsy, dementia, diabetes, and COVID-19 may outcome in novel hypotheses for identifying the etiology of these disorders.PMID:34970961 | DOI:10.2174/2589977514666211231141401
Source: Epilepsy Curr - Category: Neurology Authors: Source Type: research