Microvascular barrier protection by microRNA-183 via FoxO1 repression: A pathway disturbed in neuropathy and complex regional pain syndrome

Although widely prevalent, neuropathic and chronic pain remain a challenge to treat due to its diverse underlying etiologies, varying clinical presentations and a still incomplete molecular understanding. Complex regional pain syndrome (CRPS) is a rare primary chronic pain syndrome – occurring after fracture or surgery of an extremity. In addition to pain, common features of CRPS include allodynia, edema, sweating, temperature, skin color, and trophic changes as well as motor disturbances at the affected extremity.

Source: The Journal of Pain - December 30, 2021 Category: Materials Science Authors: Ann-Kristin Reinhold, Ellaine Salvador, Carola Y F örster, Frank Birklein, Heike L Rittner Source Type: research