Prevalence and predictors of germline CDKN2A mutations for melanoma cases from Australia, Spain and the United Kingdom

Conclusions There is a low probability (<2%) of detecting a germline CDKN2A mutation in people with melanoma except for those with a strong family history of melanoma (≥2 affected relatives, 25%), three or more primary melanomas (29%), or more than one primary melanoma who also have other affected relatives (27%).

http://link.springer.com/10.1186/1897-4287-12-20

Source: Hereditary Cancer in Clinical Practice - November 20, 2014 Category: Cancer & Oncology Source Type: research