X-ray diffraction and in vivo studies reveal the quinary structure of Trypanosoma cruzi nucleoside diphosphate kinase 1: a novel helical oligomer structure

This study constitutes the first report of such a protein arrangement, which has never previously been seen for any protein or NDPK. Further studies are needed to determine its physiological role. However, it may suggest a paradigm for protein storage reflecting the complex mechanism of action of TcNDPK1.

Source: Acta Crystallographica Section D - December 22, 2021 Category: Biochemistry Authors: Gomez Barroso, J.A. Miranda, M.R. Pereira, C.A. Garratt, R.C. Aguilar, C.F. Tags: quinary multi-hexameric X-ray structure Trypanosoma cruzi nucleoside diphosphate kinases in vivo protein granules research papers Source Type: research