Association of interleukin-12B gene polymorphisms and mRNA expression with preeclampsia

Preeclampsia (PE) is a pregnancy-specific disease characterized by hypertension and proteinuria after the 20th week of pregnancy. It affects approximately 3-5% of pregnant women and remains a major cause of maternal and neonatal morbidity and mortality worldwide [1]. Despite significant effort over many years, the exact pathogenesis of PE is still unknown. Emerging evidence suggests that PE may be an excessive maternal inflammatory response involving a T helper type 1 (Th1)/Th2 imbalance [2,3], and increases in various Th1 cytokines play an important role in the pathogenesis of PE [4,5].

Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - December 20, 2021 Category: OBGYN Authors: Ya Duan, Xinling Wang, Min Li, Cui Zhang, Sisi Li, Runfang Wang, Jian Zhao Source Type: research