Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy
We have previously demonstrated protection against obesity, metabolic dysfunction, atherosclerosis and cardiac ischemia in a hypoxia-inducible factor (HIF) prolyl 4-hydroxylase-2 (Hif-p4h-2) deficient mouse line, attributing these protective effects to activation of the hypoxia response pathway in a normoxic environment. We intended here to find out whether the Hif-p4h-2 deficiency affects the cardiac health of these mice upon aging.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tapio R öning, Johanna Magga, Anna Laitakari, Riikka Halmetoja, Joona Tapio, Elitsa Y. Dimova, Zoltan Szabo, Lea Rahtu-Korpela, Anna Kemppi, Gail Walkinshaw, Johanna Myllyharju, Risto Kerkelä, Peppi Koivunen, Raisa Serpi Source Type: research
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