Drug-eluting versus bare metal stents in saphenous vein grafts compared to native coronary vessels. The NORSTENT study.

Abstract. Background. Drug-eluting stents (DES) reduce target lesion revascularization (TLR) with no effect on mortality or myocardial infarction (MI) compared to bare metal stents (BMS) in native vessels. Randomized stent studies in saphenous vein grafts (SVG) are few and the reported effects are ambiguous. The NORSTENT study is the first to randomize lesions to percutaneous coronary intervention (PCI) in native vessels and SVG. Aims. To compare rate of mortality, MI and TLR across stent and vessel types. Methods. In this substudy 6087 patients with a single lesion in native vessels and 164 in SVG, were followed for 5 years. Results. MI was more frequent in SVG (subdistributional hazard ratio (SHR) 4.95 (3.75 – 6.54, p
Source: Cardiology - Category: Cardiology Source Type: research