An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy

This study presented that CYP450 level in HepG2/DDP cells (cisplatin-resistant cells) was higher than that in HepG2 cells, and the inhibition of CYP450 by 1-ABT effectively improved the tumor resistance. Thus, CYP450 plays a key role in the development of tumor resistance. The synergistic effect of 1-ABT and the chemotherapeutic agent cisplatin was superior to that of cisplatin alone in tumor-bearing mice. The TPE-CYP probe will provide an idea for the clinical implementation of individualized tumor treatment strategies, through the accurate monitoring of CYP450.PMID:34861484 | DOI:10.1016/j.talanta.2021.123111

Source: Talanta - December 3, 2021 Category: Chemistry Authors: Pengpeng Lu Yan Huang Caiyun Zhang Lili Fu Xiaoyan Wang Lingxin Chen Source Type: research