My approach to intraductal bile duct proliferations

Intraductal proliferations of the bile duct usually involve large bile ducts, and can occur in the intrahepatic, perihilar, and extrahepatic sites. Pre-invasive grossly detectable neoplasms are currently termed as intraductal papillary neoplasms of the bile duct (IPN-B). There is cytologic and architectural heterogeneity between and within these tumors. Based on morphologic differences between intrahepatic and extrahepatic IPN-B, the tumors can be subclassified into Type 1 and Type 2. These neoplasms show a spectrum from low-grade to high-grade dysplasia and can be associated with invasive carcinoma.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: Tumours of the liver and biliary tree Source Type: research