Cetuximab resistance induced by hepatocyte growth factor is overcome by MET inhibition in KRAS, NRAS, and BRAF wild-type colorectal cancers

CONCLUSION: Patients with mCRC receiving cetuximab + FOLFIRI who presented with high plasma HGF levels had significantly worse PFS and OS. Cetuximab resistance induced by HGF was mediated by AKT and ERK activation and overcome by MET inhibition in vitro.PMID:34853888 | DOI:10.1007/s00432-021-03872-4

Source: Clinical Colorectal Cancer - December 2, 2021 Category: Cancer & Oncology Authors: Sang-A Kim Hyejoo Park Kui-Jin Kim Ji-Won Kim Ji Hea Sung Milang Nam Ju Hyun Lee Eun Hee Jung Koung Jin Suh Ji Yun Lee Se Hyun Kim Jeong-Ok Lee Jin Won Kim Yu Jung Kim Jee Hyun Kim Soo-Mee Bang Jong Seok Lee Keun-Wook Lee Source Type: research