Spectral analysis of heart sounds associated with coronary artery disease
Objective . The aim of this study was to find spectral differences of diagnostic interest in heart
sound recordings of patients with coronary artery disease (CAD) and healthy subjects. Approach .
Heart sound recordings from three studies were pooled, and patients with clear diagnostic outcomes
(positive: CAD and negative: Non-CAD) were selected for further analysis. Recordings from 1146
patients (191 CAD and 955 Non-CAD) were analyzed for spectral differences between the two groups
using Welch ’s spectral density estimate. Frequency spectra were estimated for systole and diastole
segments, and time-frequency spectra were estimated for first (S1) and second (S2) heart sound
segments. An ANCOVA model with terms for diagnosis, age, gender, and body mass index was used to
evaluate statistical significance of the diagnosis term for each time-frequency component. Main
results . Diastole and systole segments of CAD patients showed increased energy at frequencies
20 –12...
Source: Physiological Measurement - Category: Physiology Authors: Bjarke Skogstad Larsen, Simon Winther, Louise Nissen, Axel Diederichsen, Morten B øttcher, Johannes Jan Struijk, Mads Græsbøll Christensen and Samuel Emil Schmidt Source Type: research