Spectral analysis of heart sounds associated with coronary artery disease

Objective . The aim of this study was to find spectral differences of diagnostic interest in heart sound recordings of patients with coronary artery disease (CAD) and healthy subjects. Approach . Heart sound recordings from three studies were pooled, and patients with clear diagnostic outcomes (positive: CAD and negative: Non-CAD) were selected for further analysis. Recordings from 1146 patients (191 CAD and 955 Non-CAD) were analyzed for spectral differences between the two groups using Welch ’s spectral density estimate. Frequency spectra were estimated for systole and diastole segments, and time-frequency spectra were estimated for first (S1) and second (S2) heart sound segments. An ANCOVA model with terms for diagnosis, age, gender, and body mass index was used to evaluate statistical significance of the diagnosis term for each time-frequency component. Main results . Diastole and systole segments of CAD patients showed increased energy at frequencies 20 –12...
Source: Physiological Measurement - Category: Physiology Authors: Source Type: research