The Effects of Focal Electrically Administered Seizure Therapy Compared With Ultrabrief Pulse Right Unilateral Electroconvulsive Therapy on Suicidal Ideation: A 2-Site Clinical Trial

Conclusions Although limited by the open-label, nonrandomized design, FEAST showed comparable effects on suicidal ideation when compared with routine use of UB-RUL ECT. These results are encouraging and support the need for further research and a noninferiority trial.
Source: The Journal of ECT - Category: Psychiatry Tags: Original Studies Source Type: research

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Depression is common among elderly patients, and is associated with significant physical impairment1 and elevated risk of suicide.2 While antidepressants remain the mainstay of treatment for depression across the age span, geriatric patients have less physical reserve than younger patients and more significant medical comorbidities, which may limit the effectiveness of medication treatment and increase urgency for rapid relief of depressive symptoms.3 The prospective Prolonging Remission in Depressed Elderly (PRIDE) trial demonstrated that Electroconvulsive therapy (ECT) using right unilateral ultrabrief pulse stimulus pro...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Source Type: research
Conclusions: Research is needed to further assess the PC needs of HD patients and to provide care recommendations.PMID:34847736 | DOI:10.1089/jpm.2021.0308
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
Major depressive disorder (MDD) is one of the most widespread mental disorders and can result in suicide. Suicidal ideation (SI) is strongly predictive of death by suicide, and electroconvulsive therapy (ECT) is effective for MDD, especially in patients with SI. In the present study, we aimed to determine differences in resting-state functional magnetic resonance imaging (rs-fMRI) in 14 adolescents aged 12–17 with MDD and SI at baseline and after ECT. All participants were administered the Hamilton Depression Scale (HAMD) and Beck Scale for Suicide Ideation (BSSI) and received rs-fMRI scans at baseline and after ECT....
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
DiscussionPositive results from this trial could have an immediate and tremendous impact for patients with TRD. If MST demonstrates comparable antidepressant treatment efficacy to ECT, but with greater cognitive safety, it could rapidly be adopted into clinical practice. Indeed, given that the administration of MST is nearly identical to ECT, the majority of ECT facilities in North America could readily adopt MST. Furthermore, the potential for cognitive safety could lead to improved treatment acceptability. Healthcare providers, patients and care partners, and policymakers would therefore demand this form of convulsive th...
Source: Trials - Category: Research Source Type: clinical trials
This study examined the effects of electroconvulsive therapy (ECT) on suicidal ideation, suicide attempt, and emergency department use among homeless veterans receiving services in the Veterans Affairs (VA) health care system. METHODS: N...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Conclusions: ECT has the potential to reduce ED use among homeless veterans with ECT-responsive psychiatric conditions. Further study is needed on whether the treatment engagement required of ECT participants indirectly reduces use of acute services in this population.PMID:34705349 | DOI:10.4088/JCP.21m13935
Source: Journal of Clinical Psychiatry - Category: Psychiatry Authors: Source Type: research
Electroconvulsive therapy (ECT) is the most effective treatment for severe depressive disorders and is recognized as the treatment of choice in certain urgent clinical situations such as catatonic stupor, psychotic depression, and suicidal ideation with intent and plan.1 ECT is too often viewed as a treatment of ‘last resort’ for severe psychiatric disorders.1 We will discuss globus pharyngeus (GP) in the older adult as another potential indication for urgent administration of ECT, and thus far GP has not been widely discussed in this regard.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Submitted for Treatment in Geriatric Mental Health: Research in Action; edited by Jordan Karp, MD Source Type: research
Conclusions: During 6 months of continuation MST, two-thirds of participants sustained improvements in depressive symptoms without any adverse cognitive effects. Future studies of continuation MST are warranted, particularly in comparison to ECT.Trial Registration: ClinicalTrials.gov identifier: NCT01596608.PMID:34670025 | DOI:10.4088/JCP.20m13677
Source: Journal of Clinical Psychiatry - Category: Psychiatry Authors: Source Type: research
ConclusionsClinicians have an expanding pharmacopeia to address suicide potential in their patients. Some of the agents with documented antisuicide effects may also increase suicidality under specific circumstances.
Source: Brain and Behavior - Category: Neurology Authors: Tags: REVIEW Source Type: research
More News: Clinical Trials | Depression | Electroconvulsive Therapy | Psychiatry | Study | Suicide