IL-21 impairs pro-inflammatory activity of M1-like macrophages exerting anti-inflammatory effects on rheumatoid arthritis

Conclusion：For the first time, we indicated that IL-21 inhibits LPS-mediated cytokine production in RA-SF MΦs, and impairs pro-inflammatory activity of M1-like macrophages, hereby exerting anti-inflammatory effects on RA. Thus, IL-21 might not be an appropriate therapeutic target for RA.PMID:34842006 | DOI:10.1080/08916934.2021.2007374

Source: Autoimmunity - November 29, 2021 Category: Allergy & Immunology Authors: Leilei Jian Changhong Li Xinyu Wang Lin Sun Zhenzhen Ma Jinxia Zhao Source Type: research