Choriocapillaris Flow Signal Impairment in Sorsby Fundus Dystrophy

ABSTRACT Purpose To quantify choriocapillaris flow alterations in early Sorsby Fundus Dystrophy (SFD) and to investigate the relationship of the choriocapillaris flow deficits with the choroidal and outer retinal microstructure. Methods In this prospective case-control study, 18 eyes of 11 patients with early SFD and 31 eyes of 31 controls without ocular pathology underwent multimodal imaging, including spectral-domain optical coherence tomography (OCT), followed by deep-learning-based layer segmentation. OCT Angiography (OCTA) was performed to quantify choriocapillaris flow signal deficits (FDs). Differences in choriocapillaris FD density between SFD patients and controls were determined, and the relationships with choroidal thickness, retinal pigment epithelium-drusen complex (RPEDC) thickness and outer retinal layer thicknesses were analyzed using mixed model analysis. Results SFD patie nts exhibited a significantly greater choriocapillaris FD density than controls (estimate [95% CI]: +20.0% [13.3; 26.7], P
Source: Ophthalmologica - Category: Opthalmology Source Type: research