Epigenetic activation of the elongator complex sensitizes gallbladder cancer to gemcitabine therapy

CONCLUSIONS: Our findings suggest that ELP5 expression in GBC is controlled by DNA methylation-sensitive induction of PAX5. The sequential combination therapy of DAC and gemcitabine could be an efficient therapeutic strategy to overcome chemotherapy resistance in GBC.PMID:34823564 | DOI:10.1186/s13046-021-02186-0

Source: Clinical Breast Cancer - November 26, 2021 Category: Cancer & Oncology Authors: Sunwang Xu Cen Jiang Ruirong Lin Xiaopeng Wang Xiaoqiang Hu Wei Chen Xiangjin Chen Tao Chen Source Type: research