Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy

Conclusion: This case illustrates the potential fetal and neonatal complications associated with maternal topical Diclofenac medication during pregnancy resulting in antenatal closure of the DA.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Biomed Pharmacother. 2021 Sep 16;143:112161. doi: 10.1016/j.biopha.2021.112161. Online ahead of print.ABSTRACTBACKGROUND: Maternal transplacental administration of sildenafil is being considered for a variety of fetal conditions. Clinical translation also requires evaluation of fetal safety in a higher species, such as the fetal lamb. Experiments with the pregnant ewe are curtailed by minimal transplacental transfer as well as limited access to the fetus. The EXTra-uterine Environment for Neonatal Development (EXTEND) model renders the isolated fetal lamb readily accessible and allows for direct fetal administration of sil...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSIONS: In fetuses with mild or moderate LCDH, the IPaD-PI correlated with mortality and morbidity, independently from lung size. A model combining o/e LHR with IPaD-PI identified four out of five cases that eventually died, despite being considered as having non-severe pulmonary hypoplasia. This article is protected by copyright. All rights reserved.PMID:34090307 | DOI:10.1002/uog.23701
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
i A, Vian I Abstract OBJECTIVES: To test the hypothesis that estimated mean pulmonary artery pressure (MPAP) decreases and pulmonary vascular maturation assessed by the ratio of pulmonary artery flow acceleration time and ejection time (AT/ET) increases after reversal of fetal ductus arteriosus constriction, by suspension of the causal agent (polyphenol-rich foods or nonsteroidal anti-inflammatory drugs), and that these effects are independent of evolution of gestational age, inferences not yet demonstrated in the clinical setting. METHODS: This is a prospective cohort study, comparing Doppler echocardiograph...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
CONCLUSION: Compared to normal, fetuses with TGA-IVS undergo a complex redistribution of flow during the second half of the pregnancy with higher global pulmonary flow, lower ductal flow (with a negative diastolic flow at the end of pregnancy), and a smaller foramen ovale. In addition, fetal cardiac hemodynamic anomalies observed at 28-32 weeks of gestation were associated to lower postnatal tcSO2 . These observations may provide a better understanding of a premature closure of the foramen ovale and postnatal hypoxia that are specific to the physiology in TGA-IVS. This article is protected by copyri...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Discussion Infant size at birth is determined mainly by genetics, but also pregnancy and environmental factors. Large for gestational age (LGA) is defined as a mean weight> 2 standard deviations above the weight for gestational age or above the 90th percentile on growth charts (or ~4000 g on WHO growth charts). Macrosomia is a term used for a term infant who is> 4000g. Risk factors for LGA infants includes: Male infant Maternal Genetic disposition Hispanic ethnicity Diabetic Multiparity or grand parity Obesity History of previous LGA infant Prenatal ultrasound is very helpful for antenatal management. First tri...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
This report details the diagnosis and treatment with an arterial stent graft that was effective in decreasing the size of the venous aneurysm and reversing the systemic changes associated with the disease.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Case Report Source Type: research
This report details the diagnosis and treatment with an arterial stent graft that was effective in decreasing the size of the venous aneurysm and reversing the systemic changes associated with the disease.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Source Type: research
In conclusion, antenatal treatment with sildenafil improved airway morphogenesis and pulmonary vascular development, while selexipag only acted positively on pulmonary vascular development. The combination of both compounds did not act synergistically, probably because of a decreased efficiency of both compounds caused by CYP interaction and induction. These new insights create important possibilities for future treatment of pulmonary vascular abnormalities in CDH patients already in the antenatal period of life. PMID: 29745254 [PubMed - as supplied by publisher]
Source: Am J Physiol Lung Ce... - Category: Respiratory Medicine Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
Time limit: 0 Quiz-summary 0 of 20 questions completed Questions: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Information This test series requires login for attempting. You can login easily with your Facebook account (Use the CONNECT WITH icon on the upper part of right sidebar displaying t...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs
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