Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder

Ecotoxicol Environ Saf. 2021 Nov 19;228:112992. doi: 10.1016/j.ecoenv.2021.112992. Online ahead of print.ABSTRACTMCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, the effects on the circadian rhythm and thyroid in adult mice have not been studied. In this article, adult male mice received MCA at concentrations of 0, 10, 20, 30 mg/kg. The results showed that the time spending on wheel-running and rest bouts changed in different period after MCA exposure. MCA disrupted the T3 and T4 hormone homeostasis and decreased the expression of thyroid hormone synthesis genes. The histological morphology of the thyroid gland was damaged. It was suggested that MCA exposure caused circadian rhythm disorder and thyroid dysfunction.PMID:34808512 | DOI:10.1016/j.ecoenv.2021.112992
Source: Ecotoxicology and Environmental Safety - Category: Environmental Health Authors: Source Type: research