Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model
In conclusion, CIA-muscle demonstrated a good regenerative response. Myoblast numbers per fiber were not elevated, suggesting their activity results from the persistent i nflammatory signaling which also significantly hampered maintenance of muscle fiber size. A clearer picture of signaling events at cellular level in arthritis muscle may be derived from expressing data per fiber.
Source: Physiological Reports - Category: Physiology Authors: Tracey Ollewagen,
Yigael S. L. Powrie,
Kathryn H. Myburgh,
Carine Smith Tags: ORIGINAL ARTICLE Source Type: research