Accuracy of human papillomavirus tests on self-collected urine versus clinician-collected samples for the detection of cervical precancer: a systematic review and meta-analysis

CONCLUSION: Our findings indicate that HPV test with some PCR-based assay on urine versus clinician-collected samples demonstrate similar clinical accuracy to detect CIN2 or worse. It suggests that urinary HPV test may present itself as a decent alternative screening tool for the detection of cervical pre-cancer.TRIAL REGISTRATION: PROSPERO identifier: CRD42021227901.PMID:34783207 | DOI:10.3802/jgo.2022.33.e4
Source: Journal of Gynecologic Oncology - Category: OBGYN Authors: Source Type: research

Related Links:

This study demonstrates the use of a targeted HPV next generation sequencing (NGS) panel to detect and genotype all 25 carcinogenic, probably carcinogenic, and possibly carcinogenic HPV types as well as the low-risk types HPV6 and HPV11. The panel was validated using a cohort of 93 paired liquid-based cytology samples (general practitioner (GP)-collected cervical samples and cervico-vaginal self-samples (SS)). Overall, the targeted panel had a sensitivity (GP = 97.7%, SS = 92.1%) and specificity (GP = 98.0%, SS = 96.4%) similar to the commercial HPV assays, Cobas® 4800 HPV DNA test (Roche) and CLART® HPV4S ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Ginekol Pol. 2022 Jan 24. doi: 10.5603/GP.a2021.0207. Online ahead of print.ABSTRACTOBJECTIVES: Human papillomavirus (HPV) positive patients with and without endocervical polyps is compared with respect to HPV genotypes and presence of pre-invasive diseases. To our knowledge, this is the first and largest report in the literature examining the endocervical polyps in HPV positive cases.MATERIAL AND METHODS: Clinicopathological data for the first one million screening patients (n = 1060 992) from around the entire country during 2015 and 2016 were targeted for this research. Colposcopy, colposcopic surgical diagnostic proced...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
BackgroundCINtec® PLUS p16/Ki-67 dual-stained cytology (DS) is an alternative test to cytology in triaging human papillomavirus (HPV)-positive women. Dalton p16/Ki-67 Dual Stain kit employs the similar immunocytochemical detection and operating procedures with CINtec® PLUS, but its accuracy and efficacy in triaging HPV-positive women need to be evaluated.MethodsA total of 717 HPV-positive specimens of cervical exfoliated cells were included. Cytology, Dalton, and CINtec® PLUS were subsequently performed, and two DS tests were separately completed in each of the same specimens. The results of two DS tests were h...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Human papillomavirus screen in female cervical cells has demonstrated values in clinical diagnosis of precancerous lesions and cervical cancers. Human papillomavirus tests of cervical cells by utilizing Polyme...
Source: Virology Journal - Category: Virology Authors: Tags: Research Source Type: research
AbstractIntroduction Human papillomavirus (HPV) vaccination uptake is lower among foreign-born than US-born individuals, but HPV-related (e.g., cervical) cancer risks are disproportionately higher among immigrant populations. Although timely vaccination can help reduce these risks, less is known about differences in the low HPV vaccination uptake among foreign-born groups, especially Black immigrants. The purpose of this study was to examine the differences in HPV vaccination initiation among US- and foreign-born Black men and women.MethodData from the 2013 –2017 National Health Interview Survey on Black adults, aged...
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
High-risk human papillomavirus (HPV) infection is the cause of almost all cervical cancers. HPV16 is one of the main risk subtypes. Although screening programs have greatly reduced the prevalence of cervical cancer in developed countries, current diagnostic tests cannot predict if mild lesions may progress into invasive lesions or not. In the current cross-sectional and longitudinal clinical study, we found that the HPV16 E7-specific T cell response in peripheral blood mononuclear cells of HPV16-infected patients is related to HPV16 clearance. It contributes to protecting the squamous interaepithelial lesion (SIL) from fur...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsThe clinical benefit of a single cytology co-test added to an HPV-based screening program in women aged 40 –42 years appears doubtful and economically unreasonable.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Pathol Oncol Res. 2021 Dec 21;27:1609946. doi: 10.3389/pore.2021.1609946. eCollection 2021.ABSTRACTObjectives: The present study aimed to identify the predictive value of inflammatory indexes stratified according to human papillomavirus (HPV) infection status in women with FIGO 2018 stage IB∼IIA cervical cancer. We also explored the influences of HPV infection status on the survival of cervical cancer patients. Methods: We collected data for 583 women with stage IB∼IIA cervical cancer in Sun Yat-sen University Cancer Center between 2009 and 2017. The t-test, chi-squared (χ2) test and Fisher's exact test were ap...
Source: Pathology Oncology Research - Category: Pathology Authors: Source Type: research
ConclusionsThe clinical benefit of a single cytology co-test added to an HPV-based screening program in women aged 40 –42 years appears doubtful and economically unreasonable.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Purpose of review Although cervical cancer is preventable, it is the leading cancer among women in southern Africa. The association of high-risk human papillomavirus (HR-HPV) with almost all invasive cervical cancers has led to the development of effective primary and secondary prevention measures. This review focuses on updated and new evidence of the epidemiology of HPV and HPV-based secondary prevention in southern Africa. Recent findings HR-HPV prevalence in southern Africa differs between regions, and varies most by HIV prevalence and age. HR-HPV prevalence among women living with HIV (WLWH) is reported bet...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: STD: Edited by Joseph A. Duncan Source Type: research
More News: Cancer | Cancer & Oncology | Cervical Cancer | Databases & Libraries | Genital Warts | HPV Testing | Human Papillomavirus (HPV) | OBGYN | Study