Hidradenitis Suppurativa and the Metabolic Syndrome A Comparative Cross-sectional Study of 3,207 Patients.
CONCLUSIONS: We found an association between HS and diabetes, hyperlipidemia, obesity, hypertension, and metabolic syndrome among a large community-based cohort of patients with HS. Clinicians should take into account that HS patients may have one or more undiagnosed components of the metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised. This article is protected by copyright. All rights reserved. PMID: 25760289 [PubMed - as supplied by publisher]
Authors: Campos-Borges HC, Sanz-González SM, Zanón-Moreno V, Millán Salvador JM, Pinazo-Duran MD PMID: 31629562 [PubMed - as supplied by publisher]
In this study, we assessed effects of LPZ on adipocyte differentiation and function by using 3T3-L1 preadipocytes and HFD-induced obesity mice as an in vitro and in vivo model, respectively.Main methodsOil red O staining and intracellular triacylglycerol content were used to determine lipid accumulation. Glucose uptake was performed to measure mature adipocyte function. Expression of adipocyte genes was determined by qRT-PCR and immunoblotting.Key findingsLPZ has dual effects on differentiation of 3T3-L1 cells. At low concentrations, LPZ enhanced adipocyte differentiation via induction of PPARγ and C/EBPα, two ...
Publication date: Available online 20 October 2019Source: Microvascular ResearchAuthor(s): Wayne Smith, Konstantin E. Kotliar, Leandi Lammertyn, Nthai E. Ramoshaba, Walthard Vilser, Hugo W. Huisman, Aletta E. SchutteAbstractPurposeGlobally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults.MethodsW...
CONCLUSIONS: HS is associated with a variety of comorbid conditions that should be considered to perform targeted routine screening and to improve HS management. PMID: 30295448 [PubMed - as supplied by publisher]
The metabolic syndrome —otherwise called syndrome X, insulin resistance syndrome, Reaven syndrome, and “the deadly quartet”—is the name given to the aggregate of clinical conditions comprising central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dy slipidemia. It is a prothrombotic and proinflammatory state characterized by increased inflammatory cytokine activity. In addition to inflammatory dermatoses such as psoriasis, lichen planus, and hidradenitis suppurativa, metabolic syndrome is also commonly associated with accelerated athe...
ConclusionThe application of these recommendations will facilitate the dermatologist practice, and benefit HS patients’ health and quality of life.This article is protected by copyright. All rights reserved.
CONCLUSION: Emerging scientific evidence points to close associations between MetS and common dermatological diseases necessitating to integrate this perspective into clinical management of these diseases. The dermatologist is a key player in early detection of MetS. PMID: 27815622 [PubMed - as supplied by publisher]
Hidradenitis suppurativa (HS) is a chronic inflammatory dermatological disease characterized by nodules, sinus tracts, and subsequent scarring in inverse areas with a prevalence reported from 1-4% [1,2]. HS has been associated with metabolic syndrome, which is a cluster of arterial cardiovascular risk factors i.e. obesity, hypertension, diabetes, and dyslipidemia . Several of these risk factors as well as raised levels of the inflammatory marker C-reactive protein, are also linked to venous thromboembolism i.e.
ConclusionsWe found an association between HS and diabetes, hyperlipidaemia, obesity, hypertension and metabolic syndrome among a large community‐based cohort of patients with HS. Clinicians should take into account that patients with HS may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.
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