Circular RNA CELF1 drives immunosuppression and anti-PD1 therapy resistance in non-small cell lung cancer via the miR-491-5p/EGFR axis

CONCLUSION: Our data demonstrate that upregulation of circ_CELF1 elicits both oncogenic and immunoregulatory effects on the development of NSCLC. We believe that circ_CELF1 can act as a potential therapeutic target for the treatment of NSCLC.PMID:34788230 | DOI:10.18632/aging.203576

Source: Aging - November 17, 2021 Category: Biomedical Science Authors: Wen Ge Hao Chi Hua Tang Jianjun Xu Jing Wang Wan Cai Haitao Ma Source Type: research