Can ionic concentration changes due to mechanical deformation be responsible for the neurostimulation caused by focused ultrasound? A simulation study
Objective. Ultrasound stimulation is an emerging neuromodulation technique, for which the exact
mechanism of action is still unknown. Despite the number of hypotheses such as mechanosensitive ion
channels and intermembrane cavitation, they fail to explain all of the observed experimental
effects. Here we are investigating the ionic concentration change as a prime mechanism for the
neurostimulation by the ultrasound. Approach. We derive the direct analytical relationship between
the mechanical deformations in the tissue and the electric boundary conditions for the cable theory
equations and solve them for two types of neuronal axon models: Hodgkin –Huxley and C-fibre. We
detect the activation thresholds for a variety of ultrasound stimulation cases including continuous
and pulsed ultrasound and estimate the mechanical deformations required for reaching the thresholds
and generating action potentials (APs). Main results. We note that the proposed mechanism str...
Source: Physiological Measurement - Category: Physiology Authors: Vladimir Filkin, Igor Kuznetsov, Olga Antonova, Ilya Tarotin, Alexander Nemov and Kirill Aristovich Source Type: research