An Important Potential Anti-Epileptic/Anticonvulsant Active Group: A Review of 1,2,4-Triazole Groups and Their Action

This article is an attempt to systematically
review the research of triazole derivatives in the design and development of
anticonvulsant agents during the past two decades through extensive literature
research. The results show that triazole occupy a distinct niche in heterocyclic
chemistry and represent a key motif in medicinal chemistry because of their
capability to exhibit an array of properties and bioactivities, Therefore,
1,2,4-triazole seems to be an important pharmacophore, especially in the field
of antiepileptic, which is of great explored potentiality and utilized value.
Through in-depth research on this type of structure, it is believed that more
1,2,4-triazole compounds will be developed as anti-epileptic drugs for clinical
use. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Drug Research - November 10, 2021 Category: Drugs & Pharmacology Authors: Wang, Ying Liu, Dachuan Tags: Review Source Type: research