Sex-specific aspects of phospholamban cardiomyopathy: the importance and prognostic value of low-voltage ECGs

A pathogenic variant in the gene encoding phospholamban (PLN), a protein regulating calcium homeostasis of cardiomyocytes, causes PLN cardiomyopathy. It is characterized by a high arrhythmic burden and can progress into severe cardiomyopathy. Risk assessment guides ICD therapy and benefits from personalization. It is unknown whether sex-specific differences in PLN cardiomyopathy exist.

Source: Heart Rhythm - November 9, 2021 Category: Cardiology Authors: Remco de Brouwer, Laura M.G. Meems, Tom E. Verstraelen, Belend Mahmoud, Virginnio Proost, Arthur A.M. Wilde, Laurens P. Bosman, Esm ée van Drie, Paul A. van der Zwaag, J. Peter van Tintelen, Arjan C. Houweling, Maarten P. van den Berg, Rudolf A. de Boer Source Type: research