Letter to the Editor Regarding “Pulmonary Embolism Prophylaxis in Patients With COVID-19: an Emerging Issue”, Heart Lung Circ. 2021;30(10):1435–41.

I read the article by Sanidas and colleagues [1] with great interest and congratulate the authors on their excellent work. However, I would like to draw attention to several points. Recent findings suggest that SARS-CoV-2 controls the expression of host regulatory molecules such as miRNAs and transcription factors (TFs), often regulating gene expression at transcriptional and post-transcriptional levels and forming highly complex network interactions [2]. Research has identified four miRNAs (hsa-mir-9-5p, hsa-mir-324-3p, hsa-mir-1827, and hsa-mir-1277-5p) and TFs (EP300, MYC, E2F1, and SP1) that co-regulate important target genes responsible for SARS-CoV-2 host invasion [2].
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Letter to the Editor Source Type: research