Picralima nitida protects against hepatotoxicity and oxidative stress in alloxan-induced diabetic rats

AbstractPicralima nitida is widely used in herbal medicine due to its numerous health benefits. We investigated the effects of extracts ofP. nitida in alloxan-induced diabetic rats. Thirty Wistar rats were randomized into 6 groups of 5 rats each and treated as follows; Group I — normal control rats, Group II — diabetic rats treated with glibenclamide, Group III — diabetic rats not treated, Group IV — diabetic rats treated with methanol extract ofP. nitida leaf, Group V — diabetic rats treated with methanol extract ofP. nitida seed, Group VI — diabetic rats treated with methanol extract ofP. nitida root. Phytochemical analysis of the methanol extracts ofP. nitida revealed significantly (p <  0.05) higher tannin (83.183 mgTAN/g) content in the seed extract, phenolic (289.377 mgGAE/g) and flavonoid (343.681 mgQUE/g) content in the leaf extract. Administration ofP. nitida extracts resulted in steady significant (p <  0.05) decreases in the fasting blood glucose levels, AST, ALT and ALP of the alloxan-induced diabetic rats. Administration of the extracts resulted in significant (p <  0.05) increases in the activity of CAT and GSH in the serum, liver, heart and kidney of the experimental rats. Treatment with the extracts resulted in significant (p <  0.05) decreases in the LPO activity in the serum, liver, heart and kidney of the rats. The leaf, seed and root extracts ofP. nitida showed significant antidiabetic properties and protect against ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research