Chronic Prostatitis and Pelvic Pain Syndrome: Another Autoimmune Disease?

AbstractChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), characterized by chronic pain in the perineum or lower abdomen regions, is a frequent disorder in men. Previous studies demonstrated that the immune mediators, including interleukin (IL)-1 β, IL-6, interferon-γ, tumor necrosis factor-α, and immunoglobulins, are elevated in the expressed prostate secretions and seminal fluid of CP/CPPS men. The memory T, T helper 1 (Th1), Th17, and Th22 cells increase in the peripheral blood of CP/CPPS men. Additionally, prostate antigens specific-a utoreactive T cells are identified in CP/CPPS patients. After generally reviewing and comparing the inflammatory responses in autoimmune diseases and CP/CPPS, we presumed that CP/CPPS is more likely to be defined as an autoimmune disease. Thus, a better understanding of autoimmune diseases would con tribute to a deeper understanding of the CP/CPPS and provide new inspirations for the treatment of this disease.
Source: Archivum Immunologiae et Therapiae Experimentalis - Category: Allergy & Immunology Source Type: research

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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Latest News Source Type: news
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
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Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can result in considerable disability and pain. The metacarpophalangeal (MCP) joint is the most common diseased joint in RA. In clinical practice, MCP synovitis is commonly diagnosed on the basis of musculoskeletal ultrasound (MSUS) images. However, because of the vague criteria, the consistency in grading MCP synovitis based on MSUS images fluctuates between ultrasound imaging practitioners. Therefore, a new method for diagnosis of MCP synovitis is needed.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
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Source: Clinical and Experimental Rheumatology - Category: Rheumatology Authors: Source Type: research
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